TitleUDSNB 3.0 Neuropsychological Test Norms in Older Adults from a Diverse Community: Results from the Einstein Aging Study (EAS).
Publication TypeJournal Article
Year of Publication2021
AuthorsWang, C, Katz, MJ, Chang, KH, Qin, J, Lipton, RB, Zwerling, JL, Sliwinski, MJ, Derby, CA, Rabin, LA
JournalJ Alzheimers Dis
Volume83
Issue4
Pagination1665-1678
Date Published2021
ISSN1875-8908
KeywordsAged, Aging, Black People, Cognition, Databases, Factual, Ethnicity, Female, Humans, Independent Living, Male, Neuropsychological Tests, White People
Abstract

<p><b>BACKGROUND: </b>The Uniform Data Set, Version 3 Neuropsychological Battery (UDSNB3.0), from the database of the University of Washington's National Alzheimer's Coordinating Center (NACC), is widely used to characterize cognitive performance in clinical and research settings; however, norms for underrepresented community-based samples are scarce.</p><p><b>OBJECTIVE: </b>We compared UDSNB 3.0 test scores between the Einstein Aging Study (EAS), composed of racially/ethnically diverse, community-dwelling older adults aged≥70 and the NACC, and report normative data from the EAS.</p><p><b>METHODS: </b>Analyses included 225 cognitively normal EAS participants and comparable data from 5,031 NACC database participants. Linear regression models compared performance between the samples, adjusting for demographics (sex, age, education, race/ethnicity), depressive symptoms, and whether English was the first language. Linear regression models to examine demographic factors including age, sex, education and race/ethnicity as predictors for the neuropsychological tests were applied in EAS and NACC separately and were used to create a demographically adjusted z-score calculator.</p><p><b>RESULTS: </b>Cognitive performance across all domains was worse in the EAS than in the NACC, adjusting for age, sex, education, race/ethnicity, and depression, and the differences remained in visuo-construction, visuospatial memory, confrontation naming, visual attention/processing speed, and executive functioning after further adjusting for whether English was the first language. In both samples, non-Hispanic Whites outperformed non-Hispanic Blacks and more education was associated with better cognitive performance.</p><p><b>CONCLUSION: </b>Differences observed in demographic, clinical, and cognitive characteristics between the community-based EAS sample and the nationwide NACC sample suggest that separate normative data that more accurately reflect non-clinic, community-based populations should be established.</p>

DOI10.3233/JAD-210538
Alternate JournalJ Alzheimers Dis
PubMed ID34420967
PubMed Central IDPMC8805183
Grant ListR21 AG056920 / AG / NIA NIH HHS / United States
P50 AG005142 / AG / NIA NIH HHS / United States
P30 AG013846 / AG / NIA NIH HHS / United States
U10 NS077308 / NS / NINDS NIH HHS / United States
P50 AG016573 / AG / NIA NIH HHS / United States
P50 AG047266 / AG / NIA NIH HHS / United States
P30 AG010161 / AG / NIA NIH HHS / United States
P50 AG025688 / AG / NIA NIH HHS / United States
P50 AG005133 / AG / NIA NIH HHS / United States
P50 AG005138 / AG / NIA NIH HHS / United States
P50 AG047366 / AG / NIA NIH HHS / United States
P30 AG019610 / AG / NIA NIH HHS / United States
P30 AG028383 / AG / NIA NIH HHS / United States
P50 AG033514 / AG / NIA NIH HHS / United States
P30 AG013854 / AG / NIA NIH HHS / United States
P30 AG053760 / AG / NIA NIH HHS / United States
P30 AG066444 / AG / NIA NIH HHS / United States
P30 AG010124 / AG / NIA NIH HHS / United States
P50 AG023501 / AG / NIA NIH HHS / United States
P50 AG005131 / AG / NIA NIH HHS / United States
P30 AG010133 / AG / NIA NIH HHS / United States
P50 AG016574 / AG / NIA NIH HHS / United States
P50 AG005146 / AG / NIA NIH HHS / United States
P30 AG035982 / AG / NIA NIH HHS / United States
P50 AG008702 / AG / NIA NIH HHS / United States
U01 AG016976 / AG / NIA NIH HHS / United States
R01 AG042595 / AG / NIA NIH HHS / United States
P30 AG008051 / AG / NIA NIH HHS / United States
P50 AG005681 / AG / NIA NIH HHS / United States
P50 AG005136 / AG / NIA NIH HHS / United States
P30 AG049638 / AG / NIA NIH HHS / United States
P30 AG012300 / AG / NIA NIH HHS / United States
P50 AG005134 / AG / NIA NIH HHS / United States
P30 AG008017 / AG / NIA NIH HHS / United States
P50 AG047270 / AG / NIA NIH HHS / United States
R01 NS082432 / NS / NINDS NIH HHS / United States
P01 AG003949 / AG / NIA NIH HHS / United States
P30 AG010129 / AG / NIA NIH HHS / United States