Title | UDSNB 3.0 Neuropsychological Test Norms in Older Adults from a Diverse Community: Results from the Einstein Aging Study (EAS). |
Publication Type | Journal Article |
Year of Publication | 2021 |
Authors | Wang, C, Katz, MJ, Chang, KH, Qin, J, Lipton, RB, Zwerling, JL, Sliwinski, MJ, Derby, CA, Rabin, LA |
Journal | J Alzheimers Dis |
Volume | 83 |
Issue | 4 |
Pagination | 1665-1678 |
Date Published | 2021 |
ISSN | 1875-8908 |
Keywords | Aged, Aging, Black People, Cognition, Databases, Factual, Ethnicity, Female, Humans, Independent Living, Male, Neuropsychological Tests, White People |
Abstract | <p><b>BACKGROUND: </b>The Uniform Data Set, Version 3 Neuropsychological Battery (UDSNB3.0), from the database of the University of Washington's National Alzheimer's Coordinating Center (NACC), is widely used to characterize cognitive performance in clinical and research settings; however, norms for underrepresented community-based samples are scarce.</p><p><b>OBJECTIVE: </b>We compared UDSNB 3.0 test scores between the Einstein Aging Study (EAS), composed of racially/ethnically diverse, community-dwelling older adults aged≥70 and the NACC, and report normative data from the EAS.</p><p><b>METHODS: </b>Analyses included 225 cognitively normal EAS participants and comparable data from 5,031 NACC database participants. Linear regression models compared performance between the samples, adjusting for demographics (sex, age, education, race/ethnicity), depressive symptoms, and whether English was the first language. Linear regression models to examine demographic factors including age, sex, education and race/ethnicity as predictors for the neuropsychological tests were applied in EAS and NACC separately and were used to create a demographically adjusted z-score calculator.</p><p><b>RESULTS: </b>Cognitive performance across all domains was worse in the EAS than in the NACC, adjusting for age, sex, education, race/ethnicity, and depression, and the differences remained in visuo-construction, visuospatial memory, confrontation naming, visual attention/processing speed, and executive functioning after further adjusting for whether English was the first language. In both samples, non-Hispanic Whites outperformed non-Hispanic Blacks and more education was associated with better cognitive performance.</p><p><b>CONCLUSION: </b>Differences observed in demographic, clinical, and cognitive characteristics between the community-based EAS sample and the nationwide NACC sample suggest that separate normative data that more accurately reflect non-clinic, community-based populations should be established.</p> |
DOI | 10.3233/JAD-210538 |
Alternate Journal | J Alzheimers Dis |
PubMed ID | 34420967 |
PubMed Central ID | PMC8805183 |
Grant List | R21 AG056920 / AG / NIA NIH HHS / United States P50 AG005142 / AG / NIA NIH HHS / United States P30 AG013846 / AG / NIA NIH HHS / United States U10 NS077308 / NS / NINDS NIH HHS / United States P50 AG016573 / AG / NIA NIH HHS / United States P50 AG047266 / AG / NIA NIH HHS / United States P30 AG010161 / AG / NIA NIH HHS / United States P50 AG025688 / AG / NIA NIH HHS / United States P50 AG005133 / AG / NIA NIH HHS / United States P50 AG005138 / AG / NIA NIH HHS / United States P50 AG047366 / AG / NIA NIH HHS / United States P30 AG019610 / AG / NIA NIH HHS / United States P30 AG028383 / AG / NIA NIH HHS / United States P50 AG033514 / AG / NIA NIH HHS / United States P30 AG013854 / AG / NIA NIH HHS / United States P30 AG053760 / AG / NIA NIH HHS / United States P30 AG066444 / AG / NIA NIH HHS / United States P30 AG010124 / AG / NIA NIH HHS / United States P50 AG023501 / AG / NIA NIH HHS / United States P50 AG005131 / AG / NIA NIH HHS / United States P30 AG010133 / AG / NIA NIH HHS / United States P50 AG016574 / AG / NIA NIH HHS / United States P50 AG005146 / AG / NIA NIH HHS / United States P30 AG035982 / AG / NIA NIH HHS / United States P50 AG008702 / AG / NIA NIH HHS / United States U01 AG016976 / AG / NIA NIH HHS / United States R01 AG042595 / AG / NIA NIH HHS / United States P30 AG008051 / AG / NIA NIH HHS / United States P50 AG005681 / AG / NIA NIH HHS / United States P50 AG005136 / AG / NIA NIH HHS / United States P30 AG049638 / AG / NIA NIH HHS / United States P30 AG012300 / AG / NIA NIH HHS / United States P50 AG005134 / AG / NIA NIH HHS / United States P30 AG008017 / AG / NIA NIH HHS / United States P50 AG047270 / AG / NIA NIH HHS / United States R01 NS082432 / NS / NINDS NIH HHS / United States P01 AG003949 / AG / NIA NIH HHS / United States P30 AG010129 / AG / NIA NIH HHS / United States |