TitleSocial strain and cortisol regulation in midlife in the US.
Publication TypeJournal Article
Year of Publication2012
AuthorsFriedman, EM, Karlamangla, AS, Almeida, DM, Seeman, TE
JournalSoc Sci Med
Volume74
Issue4
Pagination607-15
Date Published2012 Feb
ISSN1873-5347
KeywordsAdult, Aged, Conflict, Psychological, Family Conflict, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Interpersonal Relations, Linear Models, Male, Middle Aged, Pituitary-Adrenal System, Saliva, Social Environment, Stress, Psychological, United States
Abstract

<p>Chronic stress has been implicated in a variety of adverse health outcomes, from compromised immunity to cardiovascular disease to cognitive decline. The hypothalamic pituitary adrenal (HPA) axis has been postulated to play the primary biological role in translating chronic stress into ill health. Stressful stimuli activate the HPA-axis and cause an increase in circulating levels of cortisol. Frequent and long-lasting activation of the HPA-axis, as occurs in recurrently stressful environments, can in the long run compromise HPA-axis functioning and ultimately affect health. Negative social interactions with family and friends may be a significant source of stress in daily life, constituting the type of recurrently stressful environment that could lead to compromised HPA functioning and altered diurnal cortisol rhythms. We use data from two waves (1995 and 2004-2005) of the Midlife in the U.S. (MIDUS) study and from the National Study of Daily Experiences (NSDE) and piecewise growth curve models to investigate relationships between histories of social strain and patterns of diurnal cortisol rhythms. We find that reported levels of social strain were significantly associated with their diurnal cortisol rhythm. These effects were more pronounced for individuals with a history of greater reported strain across a ten-year period.</p>

DOI10.1016/j.socscimed.2011.11.003
Alternate JournalSoc Sci Med
PubMed ID22209675
PubMed Central IDPMC3605735
Grant ListP01-AG020166 / AG / NIA NIH HHS / United States
P30-AG028748 / AG / NIA NIH HHS / United States
R01-AG19239 / AG / NIA NIH HHS / United States
T32 HD007545 / HD / NICHD NIH HHS / United States
P30 AG028748 / AG / NIA NIH HHS / United States
R01-AG019239 / AG / NIA NIH HHS / United States
P01 AG020166 / AG / NIA NIH HHS / United States
R01 AG019239 / AG / NIA NIH HHS / United States