TitleScreening for dementia with the memory impairment screen.
Publication TypeJournal Article
Year of Publication1999
AuthorsBuschke, H, Kuslansky, G, Katz, M, Stewart, WF, Sliwinski, MJ, Eckholdt, HM, Lipton, RB
Date Published1999 Jan 15
KeywordsAged, Aged, 80 and over, Alzheimer Disease, Dementia, Diagnosis, Differential, Female, Humans, Male, Mass Screening, Memory Disorders, Mental Recall, Neuropsychological Tests, Probability, Reproducibility of Results, ROC Curve, Sensitivity and Specificity

<p><b>OBJECTIVES: </b>To validate a sensitive and specific screening test for AD and other dementias, assess its reliability and discriminative validity, and present normative data for its use in various applied settings.</p><p><b>BACKGROUND: </b>To improve discrimination in screening for AD and dementia, we developed the Memory Impairment Screen (MIS), a 4-minute, four-item, delayed free- and cued-recall test of memory impairment. The MIS uses controlled learning to ensure attention, induce specific semantic processing, and optimize encoding specificity to improve detection of dementia.</p><p><b>METHODS: </b>Equivalent forms of the MIS were given at the beginning and end of the testing session to assess alternate forms reliability. Discriminative validity was assessed in a criterion sample of 483 aged individuals, 50 of whom had dementia according to Diagnostic and Statistical Manual of Mental Disorders (3rd ed., revised) criteria.</p><p><b>RESULTS: </b>The MIS had good alternate forms reliability, high construct validity for memory impairment, and good discriminative validity in terms of sensitivity, specificity, and positive predictive value. We present normative data for use in settings with different base rates (prevalences) of AD and dementia.</p><p><b>CONCLUSION: </b>The MIS provides efficient, reliable, and valid screening for AD and other dementias.</p>

Alternate JournalNeurology
PubMed ID9932936
Grant ListAG03949 / AG / NIA NIH HHS / United States
AG12448 / AG / NIA NIH HHS / United States
HD-01799 / HD / NICHD NIH HHS / United States