TitleParental support buffers the association of depressive symptoms with cortisol and C-reactive protein during adolescence.
Publication TypeJournal Article
Year of Publication2016
AuthorsGuan, S-SAngie, Bower, JE, Almeida, DM, Cole, SW, Dahl, RE, Irwin, MR, Seeman, TE, McDade, T, Fuligni, AJ
JournalBrain Behav Immun
Date Published2016 Oct
KeywordsAdolescent, C-Reactive Protein, Depression, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Inflammation, Male, Parenting, Pituitary-Adrenal System, Social Support

<p>Social experiences can affect the relationship between depression and physical health. The current study examined how social support from parents and friends may moderate the association of depressive symptoms with hypothalamic-pituitary-adrenal (HPA) axis activity and C-reactive protein among adolescents (N=316, Mage=16.40, SD=.74; 57% female) from diverse ethnic backgrounds (23.1% Asian, 29.1% European, 41.8% Latino, and 6.0% other backgrounds). Results indicated that parent support, but not friend support, moderated the link between depressive symptoms and both total daily cortisol output (a measure HPA activity) and C-reactive protein (a marker of inflammation). These patterns did not differ by ethnicity. Overall, the study highlights the continued, and perhaps accumulated, importance of parents during adolescence despite increasing needs for autonomy from and exploration outside of the family unit.</p>

Alternate JournalBrain Behav Immun
PubMed ID26995316
PubMed Central IDPMC5010993
Grant ListR24 HD041022 / HD / NICHD NIH HHS / United States
P30 AG028748 / AG / NIA NIH HHS / United States
R01 HD062547 / HD / NICHD NIH HHS / United States
P30 AG017265 / AG / NIA NIH HHS / United States
P2C HD041022 / HD / NICHD NIH HHS / United States