TitleModality dependent changes in event-related potentials correlate with specific cognitive functions in nondemented patients with Parkinson's disease.
Publication TypeJournal Article
Year of Publication1995
AuthorsBodis-Wollner, I, Borod, JC, Cicero, B, Haywood, CS, Raskin, S, Mylin, L, Sliwinski, M, Falk, A, Yahr, MD
JournalJ Neural Transm Park Dis Dement Sect
Date Published1995
KeywordsCognition, Cognition Disorders, Dementia, Event-Related Potentials, P300, Evoked Potentials, Auditory, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease, Photic Stimulation, Verbal Behavior, Visual Perception, Wechsler Scales

<p>The relationship between event-related potentials (ERPs) and cognitive functioning was studied in patients with Parkinson's Disease (PD) but without dementia. Auditory and visual stimuli were used; 30 subjects participated in the auditory study and 20 in the visual study. Patient groups did not differ with respect to gender, age, education, illness duration, and level of cognitive functioning. Visual stimuli were 2.3 cpd sinusoidal grating patterns randomly presented in an oddball paradigm (oblique vs. vertical spatial orientation). Auditory stimuli were tones presented at 70 dB SPL at a rate of 1.1/second, also using the oddball paradigm (1.5K vs. 1K tones). All patients were given neuropsychological tests to measure verbal fluency, memory, visual spatial perception, and abstract reasoning. P300 and N200 abnormalities correlated with a number of these measures, such that longer ERP latencies were related to lower scores on tests of cognitive functioning. Patterns of results suggest that auditory and visual ERPs correlate with different subsets of neuropsychological functions in nondemented PD patients and that N200 may provide a new metric for clinical use.</p>

Alternate JournalJ Neural Transm Park Dis Dement Sect
PubMed ID8527004
Grant ListEY1708 / EY / NEI NIH HHS / United States
NS11631 / NS / NINDS NIH HHS / United States
RR71 / RR / NCRR NIH HHS / United States