TitleIngestion of transient receptor potential channel agonists attenuates exercise-induced muscle cramps.
Publication TypeJournal Article
Year of Publication2017
AuthorsCraighead, DH, Shank, SW, Gottschall, JS, Passe, DH, Murray, B, Alexander, LM, W Kenney, L
JournalMuscle Nerve
Date Published2017 Sep
KeywordsAdult, Beverages, Calcium Channels, Cross-Over Studies, Double-Blind Method, Eating, Electromyography, Exercise, Female, Humans, Male, Muscle Cramp, Muscle Fatigue, Muscle, Skeletal, Nerve Tissue Proteins, Transient Receptor Potential Channels, TRPA1 Cation Channel, TRPV Cation Channels, Young Adult

<p><b>INTRODUCTION: </b>Exercise-associated muscle cramping (EAMC) is a poorly understood problem that is neuromuscular in origin. Ingestion of transient receptor potential (TRP) channel agonists has been efficacious in attenuating electrically induced muscle cramps. This study examines the effect of TRP agonist ingestion on voluntarily induced EAMC and motor function.</p><p><b>METHODS: </b>Study 1: Thirty-nine participants completed 2 trials after ingesting TRP agonist-containing active treatment (A), or vehicle (V) control. Cramping in the triceps surae muscle was induced via voluntary isometric contraction. Study 2: After ingesting A or V, 31 participants performed kinematic and psychomotor tests of manual dexterity.</p><p><b>RESULTS: </b>A increased precramp contraction duration (A, 36.9 ± 4.1 s; V, 27.8 ± 3.1 s), decreased cramp EMG area under the curve (A, 37.3 ± 7.7 %EMG ·s; V, 77.2 ± 17.7 %EMG ·s), increased contraction force to produce the cramp (A, 13.8 ± 1.8 kg; V, 9.9 ± 1.6 kg), and decreased postcramp soreness (A, 4.1 ± 0.3 arbitrary units (a.u.); V, 4.7 ± 0.3 a.u.). Kinematic and psychomotor tests were not affected.</p><p><b>DISCUSSION: </b>TRP agonist ingestion attenuated EAMC characteristics without affecting motor function. Muscle Nerve 56: 379-385, 2017.</p>

Alternate JournalMuscle Nerve
PubMed ID28192854
PubMed Central IDPMC5554746
Grant ListT32 AG049676 / AG / NIA NIH HHS / United States
T32 DK007135 / DK / NIDDK NIH HHS / United States