TitleInfluence of Perceived Stress on Incident Amnestic Mild Cognitive Impairment: Results From the Einstein Aging Study.
Publication TypeJournal Article
Year of Publication2016
AuthorsKatz, MJ, Derby, CA, Wang, C, Sliwinski, MJ, Ezzati, A, Zimmerman, ME, Zwerling, JL, Lipton, RB
JournalAlzheimer Dis Assoc Disord
Date Published2016 Apr-Jun
KeywordsAged, Aged, 80 and over, Apolipoprotein E4, Cognitive Dysfunction, Dementia, Depression, Disease Progression, Female, Humans, Longitudinal Studies, Male, Neuropsychological Tests, Risk Factors, Sex Factors, Stress, Psychological

<p>Stress is a potentially remediable risk factor for amnestic mild cognitive impairment (aMCI). Our objective is to determine whether perceived stress predicts incident aMCI and to determine if the influence of stress on aMCI is independent of known aMCI risk factors, particularly demographic variables, depression, and apolipoprotein genotype. The Einstein Aging Study is a longitudinal community-based study of older adults. The Perceived Stress Scale (PSS) was administered annually in the Einstein Aging Study to participants (N=507; 71 developed incident aMCI; mean follow-up time=3.6 y, SD=2.0) who were aged 70 years and older, free of aMCI and dementia at baseline PSS administration, and had at least 1 subsequent annual follow-up. Cox hazard models were used to examine time to aMCI onset adjusting for covariates. High levels of perceived stress are associated with a 30% greater risk of incident aMCI (per 5-point increase in PSS: hazard ratio=1.30; 95% confidence interval, 1.08-1.58) independent of covariates. The consistency of results after covariate adjustment and the lack of evidence for reverse causation in longitudinal analyses suggest that these findings are robust. Understanding of the effect of perceived stress on cognition may lead to intervention strategies that prevent the onset of aMCI and Alzheimer dementia.</p>

Alternate JournalAlzheimer Dis Assoc Disord
PubMed ID26655068
PubMed Central IDPMC4877262
Grant ListP01 AG003949 / AG / NIA NIH HHS / United States
R01 AG039409 / AG / NIA NIH HHS / United States
R03 AG045474 / AG / NIA NIH HHS / United States
UL1 TR001073 / TR / NCATS NIH HHS / United States