TitleThe association of late-life depression and anxiety with physical disability: a review of the literature and prospectus for future research.
Publication TypeJournal Article
Year of Publication2001
AuthorsLenze, EJ, Rogers, JC, Martire, LM, Mulsant, BH, Rollman, BL, Dew, MA, Schulz, R, Reynolds, CF
JournalAm J Geriatr Psychiatry
Volume9
Issue2
Pagination113-35
Date Published2001 Spring
ISSN1064-7481
KeywordsActivities of Daily Living, Aged, Aged, 80 and over, Anxiety, Depression, Frail Elderly, Humans, Middle Aged, Persons with Disabilities, Research, Risk Factors
Abstract

<p>Depression and anxiety disorders are associated with excess disability. The authors searched the recent geriatric literature for studies associating late-life depression or anxiety with physical disability. Studies showed depression in old age to be an independent risk factor for disability; similarly, disability was found to be a risk factor for depression. Anxiety in late life was also found to be a risk factor for disability, although not necessarily independently of depression. Increased disability due to depression is only partly explained by differences in socioeconomic measures, medical conditions, and cognition. Physical disability improves with treatment for depression; comparable studies have not been done for anxiety. The authors discuss how these findings inform current concepts of physical disability and discuss the implications for future intervention studies of late-life depression and anxiety disorders.</p>

Alternate JournalAm J Geriatr Psychiatry
PubMed ID11316616
Grant ListK01 MH01613 / MH / NIMH NIH HHS / United States
K05 MH00295 / MH / NIMH NIH HHS / United States
P30 MH 52247 / MH / NIMH NIH HHS / United States
R01 MH37869 / MH / NIMH NIH HHS / United States
R01 MH59318 / MH / NIMH NIH HHS / United States
R37MH43832 / MH / NIMH NIH HHS / United States
T32 MH19986 / MH / NIMH NIH HHS / United States