Sean Shank

My research focuses on vascular function in aging and disease. Specifically, I am interested in the underlying mechanisms contributing to hypertension in cardiovascular disease. Vascular dysfunction in hypertension and other diseases is characterized by the inability (or reduced ability) of the vessel to dilate in response to a given stimulus. Recent work has suggested a role for Hydrogen Sulfide in the regulation of vascular tone and my current work is focused on understanding this role and its underlying mechanisms. Additionally, I am interested in evaluating the role that stress may have on vascular function as well as how vascular diseases such as hypertension may contribute to cognitive function and well-being.